Replication Data for: Enteric dysfunction and enteropathogens among hospitalized south Asian and sub-Saharan African children

This is a replication dataset for the manuscript titled: \"Enteric dysfunction and enteropathogens among hospitalized south Asian and sub-Saharan African children.\" This dataset contains the entire dataset of enteric biomarkers and quantitive polymerase chains reaction for enteric pathogens. Enteropathogen prevalence and fecal ED biomarkers (myeloperoxidase, calprotectin, α-1-antitrypsin) from children aged 2-23 months hospitalized at nine LMIC facilities (n=811) were compared to community children (n=248). Host and pathogen correlates of ED biomarkers were identified through crude and adjusted linear mixed effect models, and Cox-proportional hazard models assessed ED biomaker associations with inpatient and post-discharge mortality. The data collection CRFs and SOPs are available on our website at: https://chainnetwork.org/resources/.

本数据集为题为《住院南亚与撒哈拉以南非洲儿童肠道功能障碍与肠道病原体》的学术论文的复现数据集。本数据集包含肠道病原体相关的肠道生物标志物及定量聚合酶链式反应检测的全部数据。本研究对9所低收入和中等收入国家（Low- and Middle-Income Countries, LMIC）医疗机构中收治的811名2~23月龄住院儿童的肠道病原体检出率、粪便肠道功能障碍（Enteric Dysfunction, ED）生物标志物（髓过氧化物酶、钙卫蛋白、α-1抗胰蛋白酶）数据，与248名社区儿童进行了对比。通过粗线性混合效应模型与校正线性混合效应模型，明确了肠道功能障碍生物标志物的宿主与病原体相关影响因素；同时采用Cox比例风险模型，分析了肠道功能障碍生物标志物与住院期间及出院后死亡率的关联。本研究的数据收集病例报告表（Case Report Forms, CRFs）与标准操作规程（Standard Operating Procedures, SOPs）可通过以下网址获取：https://chainnetwork.org/resources/。