Vietnamese study of fetuses with clinical anomalies during pregnancy

Comprehensive data about pathogenic CNVs will assist clinicians in providing better patient counseling about the risk of genetic etiologies, enabling early detection and prediction of fetal outcomes, and proactively planning interventions. On this basis, we conducted a large-scale study using CNV analysis to screen 5,008 Vietnamese pregnant women in outpatient settings. We aimed to determine the frequencies of CNVs, sonography-based soft markers, and fetal structural anomalies. We also comprehensively studied the associations between abnormal CNVs, ultrasound soft makers, and fetal phenotypic anomalies.