EticaHub Labs computational protein-design dataset — Amyotrophic Lateral Sclerosis — run b9114903-0cf8-4964-9821-5ee58a3e4e0e

Computational dataset / research audit record, not a validated treatment. This individual run contains 7 archived candidates from 2 reported iterations. The pipeline-selected candidate is #4; its internal automated grade is weak. Proposed research question (not a demonstrated outcome): Validate the 45-mer's TDP-43 binding affinity and aggregation inhibition via SPR and ThT assays, then iterate structure-guided mutagenesis at non-conserved interface residues to enhance specificity over homologous RRM domains Evidence and limitations Computational predictions only. No experimental or clinical evidence is supplied. Scores, automated checks and resolved identifiers do not establish binding, novelty, efficacy, safety or medical benefit. The stored "verified" grade is an internal automated check, not peer review or independent scientific validation. Hypothesis, approach and success criteria below are proposed research, not experiments performed. Checkpoint versions, random seeds and complete tool inputs are not established by this archive export; exact rerun reproducibility is not claimed. Automated warn: Fold confidence: mean pLDDT 67 Internal publication gate: verification grade is weak Internal publication gate: no PubMed citation resolved Internal publication gate: no named target resolved in UniProt Internal publication gate: unresolved target symbols: TDP, RRM, TAR Files: evidence report, original JSON, all candidate sequences, provenance manifest, license and SHA-256 checksums. Available predicted coordinate exports are included and explicitly labelled; missing structures are not reconstructed. AI-assisted research generated by the EticaHub Labs autopilot. Deaven Mabry is credited as responsible project creator, with EticaHub Labs affiliation. Cited literature remains the work of its original authors; identifier resolution is not claim support.