Additional file 2: Table S1. of A-to-I RNA editing in the rat brain is age-dependent, region-specific and sensitive to environmental stress across generations

RNA editing sites detected with mmPCR-seq. Table S2. Primer sequences used for mmPCR-seq, Real-Time PCR and Htr2c-directed NGS. Table S3. % RNA editing in PFC and AMY of neonatal (P0) vs. adult (P60) rats. Table S4. Age-dependent changes in Htr2c isoform prevalence in PFC and AMY. Table S5. % RNA editing in neonatal (P0) and adult (P60) PFC vs. AMY. Table S6. Htr2c and ADARs correlations with significant non-synonymous editing sites. Table S7. Changes in Htr2c isoform prevalence in PFC vs. AMY at P0 and P60. Table S8. The effects of PRS on RNA editing at learning- and stress-related genes in F0, F1 and F2. Table S9. Statistical analysis of editing differences between oocytes, PFC and AMY. (XLSX 92 kb)

经mmPCR-seq技术检测获得的RNA编辑位点。表S2：用于mmPCR-seq、实时荧光定量PCR（Real-Time PCR）及靶向Htr2c的下一代测序（NGS）的引物序列。表S3：新生（P0）与成年（P60）大鼠前额叶皮层（Prefrontal Cortex, PFC）及杏仁核（Amygdala, AMY）的RNA编辑百分比。表S4：前额叶皮层与杏仁核中Htr2c亚型占比随年龄的变化情况。表S5：新生（P0）与成年（P60）大鼠前额叶皮层相较于杏仁核的RNA编辑百分比。表S6：针对显著性非同义编辑位点的Htr2c与RNA编辑腺苷脱氨酶（ADARs）的相关性分析。表S7：P0及P60龄时，前额叶皮层相较于杏仁核的Htr2c亚型占比变化。表S8：F0、F1及F2代中，多基因风险评分（Polygenic Risk Score, PRS）对学习相关与应激相关基因RNA编辑的影响。表S9：卵母细胞、前额叶皮层与杏仁核之间编辑差异的统计学分析。（XLSX格式，文件大小92 KB）