A novel conserved transcription factor Mycth_90344 regulates cellulase genes expression through controlling the Hac-1 and Cbh-1 in thermophilic fungus Myceliophthora thermophila

In thermophilic fungi, work on the ER stress and UPR signalling is largely unknown,we here identified a new Cys2His2 transcription factor and found its knockout strain with significantly decreased cellulases production on crystalline cellulose.Here, we show that loss-of-function mutations of this regulator resulted in the reduced expression of Mthac-1 via RNA-seq under Avicel and artificial ER-stress. mRNA profiles of Myceliophthora thermophila cells exposed to 4h Avicel.