Replication studies and meta-analysis.

*The direction of the effect was opposite to that of the Tsukuba cohort.LD = linkage disequilibrium; MAF = minor allele frequency.该效应的作用方向与筑波队列（Tsukuba cohort）相反。其中，LD指连锁不平衡（linkage disequilibrium），MAF指次要等位基因频率（minor allele frequency）。