Pregnancy in Patients with Non-cirrhotic Portal Hypertension: A Literature Review

Abstract Pregnancy in non-cirrhotic portal hypertension (NCPH) is an uncommon condition. Its management is challenging both to the obstetricians as well as to the gastroenterologists due to the lack of more extensive studies and standard clinical practice guidelines. These patients are at increased risk of portal hypertension (PTH) complications, especially variceal bleeding, and with an increased incidence of adverse maternal and fetal outcomes. Hence, a multidisciplinary approach is required for management of pregnancy in NCPH. This short review describes the different aspects of pregnancy with NCPH, emphasizing specific strategies for preventing and managing PTH from the preconceptional period to postpartum.

摘要：非肝硬化性门静脉高压症（non-cirrhotic portal hypertension, NCPH）患者合并妊娠属于罕见临床情况。由于相关大规模研究匮乏且缺乏标准化临床实践指南，此类患者的诊疗对产科医师与消化科医师均颇具挑战。此类患者发生门静脉高压症（portal hypertension, PTH）相关并发症（尤其是静脉曲张出血）的风险显著升高，同时母婴不良结局的发生率亦有所增加。因此，针对NCPH合并妊娠的诊疗需采用多学科协作模式。本短篇综述阐述了NCPH合并妊娠的各临床维度，重点探讨了从孕前至产后阶段预防与管理门静脉高压症的具体策略。