Data from: The global antigenic diversity of swine influenza A viruses

Swine influenza presents a substantial disease burden for pig populations
worldwide and poses a potential pandemic threat to humans. There is
considerable diversity in both H1 and H3 influenza viruses circulating in
swine due to the frequent introductions of viruses from humans and birds
coupled with geographic segregation of global swine populations. Much of
this diversity is characterized genetically but the antigenic diversity of
these viruses is poorly understood. Critically, the antigenic diversity
shapes the risk profile of swine influenza viruses in terms of their
epizootic and pandemic potential. Here, using the most comprehensive set
of swine influenza virus antigenic data compiled to date, we quantify the
antigenic diversity of swine influenza viruses on a multi-continental
scale. The substantial antigenic diversity of recently circulating viruses
in different parts of the world adds complexity to the risk profiles for
the movement of swine and the potential for swine-derived infections in
humans.

猪流感（Swine influenza）对全球猪群造成了沉重的疫病负担，同时对人类构成潜在的大流行威胁。当前在猪群中流行的H1、H3型流感病毒存在显著多样性，这源于病毒频繁从人类、鸟类跨种引入，加之全球猪群存在地理隔离。该类病毒的多数多样性已通过遗传学手段得以解析，但这些病毒的抗原多样性却尚未得到充分认知。至关重要的是，抗原多样性决定了猪流感病毒在兽疫与大流行层面的风险特征。本研究依托迄今最为全面的猪流感病毒抗原数据集，量化了跨多大陆尺度下猪流感病毒的抗原多样性。全球不同地区近期流行病毒所具备的显著抗原多样性，使得生猪调运的风险以及猪源人类感染的潜在可能性均更为复杂。