Safety and tolerability of a low glycemic load dietary intervention in adults with cystic fibrosis: A pilot study

Context: To achieve and maintain adequate weight, people with cystic fibrosis (CF) may often consume energy-dense, nutrient-poor foods high in added sugars and refined carbohydrates; however, little is known about the glycemic and metabolic effects of dietary composition in this patient population.
Objective: To investigate the safety and tolerability of a low glycemic load (LGL) diet in adults with CF and abnormal glucose tolerance (AGT).
Design: Prospective, open-label pilot study.
Intervention: Each participant followed his/her typical diet for eight weeks, then transitioned to an LGL diet via meal delivery service for eight weeks.
Participants: Ten adults with CF and AGT completed the trial. Mean age was 27.0±2.1 years, 64% were female, and all had pancreatic insufficiency.
Outcome Measures: The primary outcome was a change in weight from baseline to study completion, with safety established if no significant decline was noted. Other key safety outcomes included change in hypoglycem..., , , # Safety and tolerability of a low glycemic load dietary intervention in adults with cystic fibrosis: A pilot study

[https://doi.org/10.5061/dryad.1g1jwsv43](https://doi.org/10.5061/dryad.1g1jwsv43)

This dataset contains supplementary data for the above-titled manuscript.

## Description of the data and file structure

The supplementary material includes 3 tables and 2 figures, as follows:

* Supplementary Table 1—DXA Body Composition Data Excluding Participant #2*
* Dual x-ray absorptiometry data results showing the change in key body composition metrics from baseline (pre-low glycemic load diet initiation) to study completion (after 8 weeks of the low glycemic load diet intervention)
* The +/- values are measures of standard error (SE) across the study group (SE= standard deviation divided by the square root of the number of samples)
* A p-value of =0.05 was considered statistically significant
* Participant #2 was excluded due to a significant change in ph...

研究背景：囊性纤维化（cystic fibrosis, CF）患者为达到并维持适宜体重，常需摄入高能量、低营养且添加糖与精制碳水化合物含量较高的食物；但目前针对该患者群体膳食结构的血糖与代谢效应研究仍较为匮乏。
研究目的：探究低血糖负荷（low glycemic load, LGL）膳食方案在合并糖代谢异常（abnormal glucose tolerance, AGT）的囊性纤维化成人患者中的安全性与耐受性。
研究设计：前瞻性、开放标签预试验。
干预方案：所有受试者先维持自身常规膳食8周，随后通过配餐服务过渡至低血糖负荷膳食方案，干预周期同样为8周。
研究对象：共10名合并糖代谢异常的囊性纤维化成人患者完成本试验。受试者平均年龄为27.0±2.1岁，其中64%为女性，所有受试者均存在胰腺功能不全。
结局指标：主要结局为基线至试验结束时的体重变化，若未出现显著体重下降则判定该方案安全性达标。其他关键安全性结局包括低血糖相关变化……
# 囊性纤维化成人患者低血糖负荷膳食干预的安全性与耐受性：一项预试验
https://doi.org/10.5061/dryad.1g1jwsv43
本数据集包含上述标题论文的补充数据。

数据与文件结构说明
本补充材料包含3张表格与2幅图，具体如下：
* 补充表1——排除受试者2号的双能X线吸收法（DXA）身体成分数据
* 双能X线吸收法检测结果，展示了从基线（低血糖负荷膳食干预启动前）至试验结束（低血糖负荷膳食干预8周后）的关键身体成分指标变化
* 表中±值为研究组的标准误（standard error, SE）（标准误=标准差除以样本量的平方根）
* 本研究以p值≤0.05作为统计学显著性阈值
* 受试者2号因出现显著的变化而被排除。