Symptoms of Lower Urinary Tract Dysfunction Phenotyping Study

Lower urinary tract dysfunction (LUTD) is a condition related to the functions and/or structures of the lower urinary tract. LUTD affects both men and women, and becomes more common and frequent with age. Patients tend to exhibit a range of lower urinary tract symptoms (LUTS), but there has been a lack of understanding regarding which biological and psychosocial factors cause the symptoms to manifest and worsen. As a result, treatment and management methods for LUTS and LUTD have been unsatisfactory.

The Symptoms of Lower Urinary Tract Dysfunction Phenotyping Study (LURN) was established to gain a better understanding of lower urinary tract symptoms in an effort to improve the lives of those with LUTD. LURN participants were enrolled at multiple sites within the United States. Patients were assigned to one of four subgroups, based on their symptoms, the outcomes of clinical assessments, and other characteristics. Biological samples were collected from study participants and patients were required to complete certain assessments and examinations at standard time-points during the study period.

下尿路功能障碍（Lower urinary tract dysfunction, LUTD）是一类累及下尿路功能与/或结构的疾病。LUTD可同时影响男性与女性群体，且患病率随年龄增长逐渐升高。患者通常会表现出一系列下尿路症状（Lower urinary tract symptoms, LUTS），但目前学界对于引发此类症状出现并加重的生物学及社会心理因素仍缺乏充分认知。因此，针对LUTS与LUTD的治疗与管理手段至今仍不尽如人意。

下尿路功能障碍症状表型研究（Symptoms of Lower Urinary Tract Dysfunction Phenotyping Study, LURN）旨在通过深入解析下尿路症状，改善LUTD患者的生活质量。该研究的受试者在美国境内多家临床中心招募入组，研究人员根据受试者的症状表现、临床评估结果及其他特征将其划分为四个亚组。研究人员收集了受试者的生物学样本，并要求患者在研究周期内的标准时间节点完成指定的评估与检查项目。