Univariate and multivariable analyses for OS.

BackgroundLung carcinma, a serious disease commonly recognized at advanced stages and has less favorable outcomes to treatments. This research examines the association between D-dimer values and clinical variables in patients diagnosed with advanced lung cancer, with a focus on their prognostic significance and radiotherapy related outcomes.MethodsThis retrospective observational descriptive cohort study, including 142 patients with lung cancer. Aa comprehensive analysis, was conducted, including demographic variables,clinical staging, pathology, laboratuary tests, and D-dimer levels measured both before and after the administration of radiotherapy.ResultsThe findings indicated that high pre-RT D-dimer concentrations were significantly assoccciated with advanced stages of disease, worse response of radiotherapy, Eastern Cooperative Oncology Group performance status, and decreased survival outcomes. Radiotherapy response also affects to survival rates with D-dimer values. The findings from both univariate and multivariable survival analyses demonstrated that lower concentrations of D-dimer correlated with better response of radiotherapy, extended overall survival and progression free survival (p: ConclusionThese results illustrate the significant role of D-dimer as a valuable biomarker for assessing tumor burden and guiding radiotherapy and other treatment strategies in lung cancer, thereby necessitating further inquiry to evaluate its clinical implications.背景：肺癌是一种严重疾病，通常在晚期阶段才被确诊，且治疗预后欠佳。本研究旨在探讨确诊为晚期肺癌的患者中，D-二聚体（D-dimer）水平与临床变量之间的关联，并重点分析其预后价值以及与放射治疗相关的治疗结局。 方法：本研究为回顾性观察性描述性队列研究，共纳入142例肺癌患者。研究开展了全面分析，涵盖人口统计学变量、临床分期、病理特征、实验室检测指标，以及放射治疗前后的D-二聚体水平。 结果：研究结果显示，放射治疗前高D-二聚体水平与疾病晚期、放射治疗应答不佳、东部肿瘤协作组（Eastern Cooperative Oncology Group）体能状态评分差以及较差的生存结局显著相关。放射治疗应答同样会通过D-二聚体水平影响患者生存率。单因素及多因素生存分析结果均表明，较低的D-二聚体水平与更佳的放射治疗应答、更长的总生存期（overall survival）及无进展生存期（progression free survival）相关（p： 结论：上述结果证实，D-二聚体可作为评估肿瘤负荷、指导肺癌放射治疗及其他治疗策略的重要生物标志物，因此有必要开展进一步研究以评估其临床应用价值。