Supplementary Material for: Advanced Maternal Age and the Future Health of the Offspring

Objective: We aimed to evaluate the association between advanced maternal age and the long-term health of the offspring. Methods: In this population-based cohort study, hospitalizations of offspring up to the age of 18 years were compared according to maternal age. The incidence of long-term hospitalizations of the offspring due to cardiovascular, endocrine, neurological, hematological, respiratory and gastro­intestinal morbidities was evaluated. Deliveries occurred between the years 1991 and 2014 in a tertiary medical center. Kaplan-Meier survival curves were used to compare cumulative morbidity incidence. Cox regression models were performed to control for confounders. Results: During the study period, 202,709 deliveries were included, of which 26,287 (12.9%) were in women aged 35–39 years, and 6,718 (3.3%) in women aged 40–50 years. Children born to older mothers did not have a significantly different cumulative incidence of long-term pediatric morbidities evaluated, as compared with the comparison group, using Kaplan-Meier survival analyses. In the Cox regression analyses, advanced maternal age did not exhibit an independent association with long-term morbidities of the offspring. Conclusion: Despite the association of advanced maternal age with adverse maternal and immediate neonatal outcomes, there does not seem to be an association with the long-term morbidity of the offspring.研究目的：本研究旨在探讨产妇高龄与子代长期健康状况之间的关联。 研究方法：本项基于人群的队列研究，按产妇年龄分组，对比子代至18岁时的住院情况。本研究评估了子代因心血管、内分泌、神经、血液、呼吸及胃肠道疾病导致长期住院的发生率。所有研究对象的分娩数据均采集自1991年至2014年间某三级医疗中心。本研究采用Kaplan-Meier生存曲线（Kaplan-Meier）比较累积发病风险，并通过Cox回归模型（Cox regression）控制混杂因素。 研究结果：研究期间共纳入202709例分娩案例，其中产妇年龄为35~39岁者26287例（占比12.9%），40~50岁者6718例（占比3.3%）。经Kaplan-Meier生存分析显示，高龄母亲所产子代的长期儿科疾病累积发病风险与对照组无显著差异。Cox回归分析结果表明，产妇高龄与子代长期患病风险不存在独立相关性。 研究结论：尽管产妇高龄与不良产科结局及新生儿即刻并发症存在关联，但未发现其与子代长期发病风险存在相关性。