LEVOFLOXACIN RESIDUES IN CHICKEN MEAT AND GIBLETS

Levofloxacin is a third generation fluoroquinolone used in food-producing animals in some countries outside of EU. The aim of the study was to investigate the residues of this antibiotic in chicken tissues (meat, skin and giblets). Chicken (n=30) were treated with levofloxacin orally at a dose of 10 mg/kg BW for 5 days. Birds were divided into 5 groups and humanely killed as followed: on day 0 (the day after last administration of levofloxacin), 2, 4, 6 and 8 day. The results of the studies showed the highest residues levels of levofloxacin in liver (1051 µg/kg), followed by breast muscle, gizzard, heart and skin – 428 321 303 and 293 respectively. The rate of reduction of antimicrobial activity was different. Tissue concentrations in heart and gizzard decreased faster than these in muscles and skin. In the liver they decreased from the last day of the treatment to the 2nd day and the levels remained nearly equal up to the 8 th day after the end of drug administration.

左氧氟沙星系第三代氟喹诺酮类药物，在某些欧盟以外的国家用于食用动物。本研究旨在探究该抗生素在鸡肉组织（肉质、皮肤及内脏）中的残留情况。实验中，选取30只鸡，以每千克体重10毫克的剂量通过口服途径给予左氧氟沙星，连续使用5天。将鸡分为5组，并按以下顺序人道处死：在第0天（最后一次给药后的一天）、第2天、第4天、第6天和第8天。研究结果显示，肝组织中的左氧氟沙星残留量最高，为每千克1051微克，依次为胸肌、胃肌、心脏和皮肤，分别为每千克428、321、303和293微克。抗菌活性的降低速率存在差异。心脏和胃肌中的组织浓度下降速度较肌肉和皮肤快。在肝脏中，组织浓度从治疗最后一天下降至给药结束后的第2天，并在此后保持接近恒定的水平，直至给药结束后的第8天。