GWAS summary statistics for major depressive disorder symptoms (2024)

Meta-analysed genome-wide association summary statistics for symptoms of major depressive disorder.Clin = Clinical and case-enriched cohorts: Psychiatric Genomics Consortium, , Australian Genetics of Depression Study and Generation Scotland,Comm = Community (not selected for diagnosis) cohorts: ALSPAC, Estonian Biobank, and UK Biobank.Symptoms analysed:MDD1: Depressed mood most of the day, nearly every dayMDD2: Markedly diminished interest or pleasure in all, or almost all, activities most of the day, nearly every dayMDD3: Significant change in weight or appetiteMDD3a: Significant weight loss or decrease in appetiteMDD3b: Significant weight gain or increase in appetiteMDD4: Sleeping too much or not sleeping enoughMDD4a: Insomnia nearly every dayMDD4b: Hypersomnia nearly every dayMDD5: Changes in speed/amount of moving or speakingMDD5a: Psychomotor agitation nearly every dayMDD5b: Psychomotor slowing nearly every dayMDD6: Fatigue or loss of energy nearly every dayMDD7: Feelings of worthlessness or excessive or inappropriate guiltMDD8: Diminished ability to think or concentrate, or indecisivenessMDD9: Recurrent thoughts of death or suicide or a suicide attempt or a specific plan for attempting suicide

本数据集为针对重度抑郁症（major depressive disorder, MDD）症状的元分析全基因组关联研究汇总统计量。
临床及病例富集队列（缩写为Clin）：涵盖精神疾病基因组学联盟（Psychiatric Genomics Consortium）、澳大利亚抑郁症遗传学研究（Australian Genetics of Depression Study）以及苏格兰世代研究（Generation Scotland）。
社区队列（缩写为Comm，未基于诊断进行招募筛选）：涵盖雅芳纵向父母与儿童研究（Avon Longitudinal Study of Parents and Children, ALSPAC）、爱沙尼亚生物样本库（Estonian Biobank）以及英国生物样本库（UK Biobank）。
本次分析的症状条目如下：
MDD1：整日且几乎每日情绪低落
MDD2：整日且几乎每日对绝大多数或全部活动明显丧失兴趣或愉悦感
MDD3：体重或食欲出现显著变化
MDD3a：显著体重下降或食欲减退
MDD3b：显著体重上升或食欲亢进
MDD4：睡眠过多或睡眠不足
MDD4a：几乎每日失眠
MDD4b：几乎每日嗜睡
MDD5：动作或言语的速度与数量发生改变
MDD5a：几乎每日出现精神运动性激越
MDD5b：几乎每日出现精神运动性迟滞
MDD6：几乎每日感到疲乏或精力丧失
MDD7：存在无用感或过度且不当的内疚感
MDD8：思考或集中注意力的能力下降，或犹豫不决
MDD9：反复出现死亡或自杀念头、自杀未遂或存在具体自杀计划