(Z)‑Selective Hydrosilylation of Terminal Alkynes with HSiMe(OSiMe3)2 Catalyzed by a Ruthenium Complex Containing an N‑Heterocyclic Carbene

The N-heterocyclic-carbene-ligated ruthenium complex [RuHCl­(CO)­(H2IMes)­(PCy3)] exhibits high catalytic activity for the (Z)-selective hydrosilylation of various terminal alkynes with 1,1,1,3,5,5,5-heptamethyl­trisiloxane (HSiMe­(OSiMe3)2). The stereoretentive derivatization of the (Z)-alkenylsiloxanes allows the synthesis of biologically active compounds, e.g. potent antitumor agents and inhibitors for induced-NO synthase.氮杂环卡宾配位的钌配合物[RuHCl(CO)(H₂IMes)(PCy₃)]对各类末端炔烃与1,1,1,3,5,5,5-七甲基三硅氧烷(HSiMe(OSiMe₃)₂)的(Z)选择性氢化硅烷化反应展现出优异的催化活性。(Z)-烯基硅氧烷的立体保留衍生化可用于合成具有生物活性的化合物，例如强效抗肿瘤剂以及诱导型一氧化氮合酶抑制剂。