Additional file 1 of Assessing causality between inflammatory bowel diseases with frailty index and sarcopenia: a bidirectional Mendelian randomization study

Additional file 1: Figure S1. Causal effect and sensitivity analysis of UC-associated single nucleotide polymorphisms on FI. (A) A forest chart illustrating the causative impacts of years of UC-related SNPs on the FI. (B) A sensitivity analysis was performed to explore the likelihood that the causal link was propelled by a distinctive SNP. Figure S2. Investigation into the causative role and sensitivity analysis of CD-associated SNPs on FI. (A) Forest plot depicting the causal effects of the duration of CD-linked single nucleotide polymorphisms on FI. (B) A detailed sensitivity review was carried out to explore the possibility that a unique SNP was the driving factor behind the causal association. Figure S3. Investigation into the causative role and sensitivity analysis of UC-linked SNPs on sarcopenia. (A) Forest plot illustrating the causal implications of the duration of UC-related SNPs on sarcopenia. (B) A detailed sensitivity review was conducted to assess the potential that a unique SNP was the driving force behind the causal association. Figure S4. Investigation into the causative influence and sensitivity examination of CD-related SNPs on sarcopenia. (A) Forest plot displaying the causal effects of the duration of CD-related SNPs on sarcopenia. (B) A detailed sensitivity review was carried out to evaluate the probability that a distinct SNP was the driving factor behind the causal association. Figure S5. Analysis of the causative role and sensitivity assessment of FI-linked SNPs in UC. (A) Forest plot depicting the causal impacts of the duration of FI-related SNPs on UC. (B) A sensitivity examination conducted to delve into the likelihood that the causal link was driven by a distinctive SNP. Figure S6. Analysis of the causative role and sensitivity study of FI-related SNPs in CD. (A) Forest plot demonstrating the causal effects of the duration of FI-linked single nucleotide polymorphisms on CD. (B) A detailed sensitivity review was carried out to assess the possibility that a unique SNP was the driving factor behind the causal association. Figure S7. Investigation into the causative influence and sensitivity assessment of sarcopenia-linked SNPs on UC. (A) Forest plot illustrating the causal implications of years of sarcopenia-associated SNPs on UC. (B) A sensitivity analysis conducted to probe into the likelihood that the causal connection was instigated by a distinct SNP. Figure S8. Investigation into the causative influence and sensitivity assessment of sarcopenia-linked SNPs on CD. (A) Forest plot illustrating the causal implications of years of sarcopenia-associated SNPs on CD. (B) A sensitivity analysis conducted to probe into the likelihood that the causal connection was instigated by a distinct SNP.附加文件1：图S1 溃疡性结肠炎（Ulcerative Colitis, UC）相关单核苷酸多态性（single nucleotide polymorphism, SNP）对粪便失禁（Fecal Incontinence, FI）的因果效应及敏感性分析。(A) 森林图展示了UC病程相关单核苷酸多态性对FI的因果影响。(B) 开展敏感性分析以探究该因果关联由某一特定SNP驱动的可能性。 图S2 克罗恩病（Crohn's Disease, CD）相关单核苷酸多态性对FI的因果作用及敏感性分析。(A) 森林图描绘了CD病程相关单核苷酸多态性对FI的因果效应。(B) 开展详细敏感性分析以探究某一独特SNP驱动该因果关联的可能性。 图S3 溃疡性结肠炎相关单核苷酸多态性对肌肉减少症的因果作用及敏感性分析。(A) 森林图展示了UC病程相关单核苷酸多态性对肌肉减少症的因果影响。(B) 开展详细敏感性评估以探究某一特定SNP驱动该因果关联的可能性。 图S4 克罗恩病相关单核苷酸多态性对肌肉减少症的因果作用及敏感性分析。(A) 森林图展示了CD病程相关单核苷酸多态性对肌肉减少症的因果效应。(B) 开展详细敏感性分析以评估某一独特SNP驱动该因果关联的概率。 图S5 粪便失禁相关单核苷酸多态性在UC中的因果作用及敏感性评估。(A) 森林图描绘了FI病程相关单核苷酸多态性对UC的因果影响。(B) 开展敏感性分析以探究该因果关联由某一特定SNP驱动的可能性。 图S6 粪便失禁相关单核苷酸多态性在CD中的因果作用及敏感性研究。(A) 森林图展示了FI病程相关单核苷酸多态性对CD的因果效应。(B) 开展详细敏感性分析以评估某一独特SNP驱动该因果关联的可能性。 图S7 肌肉减少症相关单核苷酸多态性对UC的因果作用及敏感性评估。(A) 森林图展示了肌肉减少症病程相关单核苷酸多态性对UC的因果影响。(B) 开展敏感性分析以探究该因果关联由某一特定SNP诱发的可能性。 图S8 肌肉减少症相关单核苷酸多态性对CD的因果作用及敏感性评估。(A) 森林图展示了肌肉减少症病程相关单核苷酸多态性对CD的因果影响。(B) 开展敏感性分析以探究该因果关联由某一特定SNP诱发的可能性。