A novel animal model for secondary progressive multiple sclerosis by oligodendroglia-specific conditional connexin 47 knockout [Affy]
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE121337
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资源简介：
Objective: To elucidate the role of Cx47 loss in chronic neuroinflammation and establish an SPMS model. Methods: Plp-CreERT; Cx47fl/fl mice were generated and administered tamoxifen to induce oligodendroglia-specific conditional knockout of Cx47 (Cx47 icKO). Ten days after tamoxifen treatment, Cx47 icKO mice and their control littermates were immunized by myelin oligodendrocyte glycoprotein peptide 35-55 to induce experimental autoimmune encephalomyelitis (EAE). FL naive MG as control.
创建时间：
2018-10-20
