Supplementary Material for: Epidemiology of Hypertension among Patients on Peritoneal Dialysis Using Standardized Office and Ambulatory Blood Pressure Recordings

<b><i>Introduction:</i></b> Prior studies conducted in peritoneal dialysis (PD) patients in the late 1990s provided considerably variable estimates of the prevalence and control of hypertension. The present study aimed to investigate the current state of hypertension management in this high-risk population. <b><i>Methods:</i></b> In 140 stable PD patients, we performed standardized automated office blood pressure (BP) measurements and 24-h ambulatory BP monitoring (ABPM) using the Mobil-O-Graph device (IEM, Germany). Office and ambulatory hypertension was diagnosed in patients with office BP ≥140/90 mm Hg and 24-h BP ≥130/80 mm Hg, respectively. Patients treated with ≥1 BP-lowering medications were also classified as hypertensives. <b><i>Results:</i></b> The prevalence of office and ambulatory hypertension was 92.9% and 95%, respectively. In all, 92.1% of patients were being treated with an average of 2.4 BP-lowering medications daily. Adequate BP control was achieved in 52.3% and 38.3% of hypertensives by office BP and ABPM, respectively. The agreement between these 2 techniques in the identification of patients with BP levels above the diagnostic thresholds of hypertension was moderate (<i>k</i>-statistic: 0.524). In all, 5% of patients were normotensives with both techniques, 31.4% had controlled hypertension, 5% had white-coat hypertension, 19.3% had masked hypertension, and 39.3% had sustained hypertension. Isolated nocturnal hypertension was detected in 23.6% of patients, whereas no patient had isolated daytime hypertension. <b><i>Conclusion:</i></b> Among PD patients, hypertension is highly prevalent and remains often inadequately controlled. The use of ABPM enables the better classification of severity of hypertension and identification of isolated nocturnal hypertension, which is a common BP phenotype in the PD population.

<b><i>引言：</i></b> 20世纪90年代末针对腹膜透析（peritoneal dialysis, PD）患者开展的既往研究，对高血压的患病率与控制情况给出了差异显著的评估结果。本研究旨在探究这一高危人群的高血压管理现状。
<b><i>研究方法：</i></b> 本研究纳入140例病情稳定的PD患者，采用德国IEM公司生产的Mobil-O-Graph设备，对其开展标准化自动化诊室血压（blood pressure, BP）测量与24小时动态血压监测（ambulatory BP monitoring, ABPM）。诊室血压≥140/90 mmHg、24小时动态血压≥130/80 mmHg的患者，分别被诊断为诊室高血压与动态高血压；同时，接受≥1种降压药物治疗的患者也被归类为高血压患者。
<b><i>研究结果：</i></b> 诊室高血压与动态高血压的患病率分别为92.9%与95%。总计92.1%的患者接受了平均每日2.4种降压药物的治疗。通过诊室血压与动态血压监测评估，分别有52.3%与38.3%的高血压患者实现了血压的良好控制。两种检测方法在识别血压超过高血压诊断阈值的患者时，一致性程度中等（<i>k</i>统计量：0.524）。总计5%的患者经两种检测均为血压正常者；31.4%的患者高血压得到控制，5%存在白大衣高血压，19.3%存在隐性高血压，39.3%存在持续性高血压。23.6%的患者被检出孤立性夜间高血压，而无患者存在孤立性日间高血压。
<b><i>结论：</i></b> PD患者群体中，高血压患病率极高，且多数患者的血压控制仍不充分。动态血压监测（ABPM）的应用可实现高血压严重程度的更精准分级，同时能够识别出PD人群中常见的孤立性夜间高血压这一血压表型。