Diabetes Mellitus in Nepal from 2000 to 2020: A systematic review and meta-analysis

The systematic review was registered in PROSPERO (CRD42020215247) and was documented according to the Meta-Analysis of Observational Studies in Epidemiology (MOOSE) guidelines. We used electronic databases like PubMed, PubMed Central, Scopus, Google Scholar, and Embase to search relevant articles from 2000 to 2020 using the appropriate keywords like “diabetes mellitus”, “high blood sugar”, “type 2 diabetes”, “prevalence”, “risk factor” and “Nepal” along with relevant Boolean operators. The eligibility criteria for inclusion were:1. All papers (cross-sectional studies, case series reporting more than 50 patients, cohort study, RCTs) mentioning prevalence of Type 2 DM and/or detail of DM like risk factors, outcome, and outcome predictors 2. Studies conducted from 2000 onwards till 2020 3. Studies in Nepal only. 4. Published articles. We excluded 1. Editorials, commentaries, viewpoint articles with no proper data of diabetes mellitus and lacking adequate data of interest will be excluded. 2. Studies conducted outside Nepal.<b> </b> 3. Studies before 1999 AD.4. Studies of Type 1 DM and GDM.本系统综述已在PROSPERO系统综述注册平台（CRD42020215247）完成注册，并严格遵循《流行病学观察性研究Meta分析报告指南》（Meta-Analysis of Observational Studies in Epidemiology, MOOSE）的规范进行撰写。本研究通过PubMed、PubMed Central、Scopus、Google Scholar及Embase等电子数据库，以"糖尿病（diabetes mellitus）""高血糖（high blood sugar）""2型糖尿病（type 2 diabetes）""患病率（prevalence）""危险因素（risk factor）""尼泊尔（Nepal）"等为检索词，结合布尔逻辑运算符，检索2000年至2020年间的相关学术文献。本研究的文献纳入标准如下：1. 所有提及2型糖尿病（Type 2 DM）患病率、或涉及糖尿病相关危险因素、结局及结局预测因素等内容的文献，包括横断面研究、报告病例数≥50例的病例系列研究、队列研究及随机对照试验（Randomized Controlled Trials, RCTs）；2. 2000年及之后至2020年期间开展的研究；3. 仅在尼泊尔境内开展的研究；4. 已正式发表的文献。本研究的文献排除标准如下：1. 未提供有效糖尿病相关数据、且缺乏目标研究所需充分数据的社论、评论及观点类文章；2. 在尼泊尔以外地区开展的研究；3. 公元1999年之前开展的研究；4. 针对1型糖尿病（Type 1 DM）及妊娠期糖尿病（Gestational Diabetes Mellitus, GDM）的研究。