Replication Data for: The BCG-Corona randomized placebo-controlled trial in Dutch healthcare workers

This record includes meta-data from the BCG-Corona trial, a double-blind, placebo-controlled randomized trial comparing BCG to placebo vaccination to prevent unplanned absenteeism and COVID-19-related endpoints in healthcare workers in nine Dutch hospitals. Healthcare workers were randomized to BCG or placebo vaccination (1:1) in March and April 2020 and followed for one year. They reported daily symptoms, SARS-CoV-2 test results, and healthcare seeking behavior via a smartphone application, and donated blood for SARS-CoV-2 serology at two timepoints. BCG vaccination did not reduce unplanned absenteeism, SARS-CoV-2 infections, or SARS-CoV-2 infection duration or severity. Nasopharyngeal rest materials after SARS-CoV-2 testing were stored in two of the nine hospitals and used for 16S microbiome sequencing and viral panel testing. Those results are pending.

本数据集包含BCG-Corona试验的相关元数据。该试验为一项双盲安慰剂对照随机临床试验，旨在对比卡介苗（BCG）与安慰剂疫苗接种，以预防荷兰9家医院的医护人员出现计划外缺勤及新冠相关临床结局。研究于2020年3月至4月将医护人员按1:1比例随机分配至卡介苗组或安慰剂疫苗组，并开展为期1年的随访。受试者通过智能手机应用每日上报自身症状、新冠病毒（SARS-CoV-2）检测结果及就医行为，并在两个时间点采血进行新冠病毒血清学检测。试验结果显示，卡介苗接种未能减少计划外缺勤、新冠病毒感染、新冠病毒感染时长或感染严重程度。九家医院中的两家留存了新冠病毒检测后的鼻咽剩余样本，用于16S微生物组测序及病毒联检组合检测。目前相关研究结果尚未公布。