Supplemental Table 4

Supplemental Table 4. Gut microbiome and metabolome after 7 days treatment of tacrolimus. A) Taxonomic assignment of gut microbiota was performed to compare to gut microbiota after 2 days of tacrolimus treatment. Gut metabolome after B) 2 days of tacrolimus was compared to gut metabolome after C) 7 days of treatment. To indicate the significantly affected pathways after 7 days of tacrolimus treatment, D) pathway enrichment analysis was performed using metabolite set enrichment analyses (MSEA) (Xia and Wishart, 2010). Metabolites of the intraluminal stool using CE/MS (capillary electrophoresis-mass spectrometry) (Kawamura et al., 2018; Matsumoto et al., 2014; Sugahara et al., 2017).补充表4：他克莫司治疗7天后的肠道微生物组（gut microbiome）与代谢组（metabolome）。A) 对肠道菌群进行分类学注释，以与他克莫司治疗2天后的肠道菌群进行对照分析。将B组（他克莫司治疗2天后）的肠道代谢组与C组（治疗7天后）的肠道代谢组进行对比。D) 为明确他克莫司治疗7天后显著受影响的代谢通路，采用代谢物集富集分析（metabolite set enrichment analyses, MSEA）开展通路富集分析（Xia与Wishart，2010）。采用毛细管电泳-质谱法（capillary electrophoresis-mass spectrometry, CE/MS）对肠腔内粪便中的代谢物进行检测（Kawamura等，2018；Matsumoto等，2014；Sugahara等，2017）。