Global Parkinson's Genetics Program Data Release 6
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In December 2023, GP2 announced the sixth data release on the Terra and the Verily® Workbench platforms in collaboration with AMP® PD. This release includes >20,000 additional participants, adding to the previous releases from the Complex and Monogenic Networks. The complex disease data (genotypes), including locally-restricted samples, now consists of a total of 44,831 genotyped participants (24,709 PD cases, 17,246 Controls, and 2,876 ‘Other’ phenotypes) When removing the locally-restricted samples, these now consist of 33,436 (17,129 PD cases, 13,872 Controls, and 2,435 ‘Other’ phenotypes) The monogenic disease data (whole genome sequences) now consists of a total of 2,324 sequenced participants (1,854 PD cases, 314 Controls, and 156 ‘Other’ phenotypes) When removing the locally-restricted samples, these now consist of 2,083 (1,650 PD cases, 309 Controls, and 124 ‘Other’ phenotypes)12,585 individuals who have deep clinical phenotyping information also have matching genetic information Please see the accompanying blog for further description of this release. To obtain data access, please see https://amp-pd.org/researchers/data-use-agreement. For any publications using data from this release, please reference the DOI number and the following statement: "Data (DOI 10.5281/zenodo.10472143, release 6) used in the preparation of this article were obtained from the Global Parkinson’s Genetics Program (GP2)."
2023年12月，全球帕金森病遗传学项目（Global Parkinson’s Genetics Program, GP2）联合AMP® PD，在Terra与Verily® Workbench平台发布第六版数据集。本次发布新增逾20000名参与者，扩充自复杂疾病与单基因疾病网络此前发布的数据集。 复杂疾病基因型数据（含本地受限样本）目前总计纳入44831名经基因分型的参与者，其中帕金森病（Parkinson’s Disease, PD）病例24709例、健康对照17246例，其余2876例为“其他”表型。若剔除本地受限样本，该数据集共包含33436名参与者，其中PD病例17129例、健康对照13872例，其余2435例为“其他”表型。 单基因疾病全基因组测序数据目前总计纳入2324名经全基因组测序的参与者，其中PD病例1854例、健康对照314例，其余156例为“其他”表型。若剔除本地受限样本，该数据集共包含2083名参与者，其中PD病例1650例、健康对照309例，其余124例为“其他”表型。此外，另有12585名受试者同时拥有深度临床表型分型信息与匹配的遗传数据。 如需了解本次数据集发布的更多详情，请参阅配套发布博客。如需获取数据访问权限，请访问https://amp-pd.org/researchers/data-use-agreement。若使用本版数据集开展研究并发表学术成果，请引用该数据集的DOI编号及如下声明：“本文所用数据（DOI：10.5281/zenodo.10472143，第六版）源自全球帕金森病遗传学项目（GP2）。”
