Crystal structure of human carbonic anhydrase II with 3-(3-((1-(2-(hydroxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl)-1H-1,2,3-triazol-4-yl)methyl)ureido)benzenesulfonamide

Crystal structure of human carbonic anhydrase II with 3-(3-((1-(2-(hydroxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl)-1H-1,2,3-triazol-4-yl)methyl)ureido)benzenesulfonamide Descriptor: 3-(3-((1-(2-(hydroxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl)-1H-1,2,3-triazol-4-yl)methyl)ureido)benzenesulfonamide, Carbonic anhydrase 2, GLYCEROL, ... Authors: Angeli, A, Ferraroni, M. Deposit date: 2021-02-10 Release date: 2022-02-23 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.28 Å) Cite: Mechanisms of the Antiproliferative and Antitumor Activity of Novel Telomerase-Carbonic Anhydrase Dual-Hybrid Inhibitors. J.Med.Chem., 64, 2021

人类碳酸酐酶II（human carbonic anhydrase II）与3-(3-((1-(2-(羟甲基)-5-(5-甲基-2,4-二氧代-3,4-二氢嘧啶-1(2H)-基)四氢呋喃-3-基)-1H-1,2,3-三唑-4-基)甲基)脲基)苯磺酰胺的复合物晶体结构。描述项：3-(3-((1-(2-(羟甲基)-5-(5-甲基-2,4-二氧代-3,4-二氢嘧啶-1(2H)-基)四氢呋喃-3-基)-1H-1,2,3-三唑-4-基)甲基)脲基)苯磺酰胺、碳酸酐酶2（Carbonic anhydrase 2）、甘油（GLYCEROL）等。作者：Angeli, A、Ferraroni, M。提交日期：2021-02-10；发布日期：2022-02-23；最后修改日期：2024-01-31。实验方法：X射线衍射（X-RAY DIFFRACTION，分辨率1.28 Å）。引用文献：《新型端粒酶-碳酸酐酶双杂合抑制剂的抗增殖与抗肿瘤活性机制》，《Journal of Medicinal Chemistry》，2021年，第64卷。