Catalytic Decarboxylative Alkenylation of Enolates

A palladium-catalyzed decarboxylative alkenylation of stabilized enolates has been developed, which gives rise to alkenylated dicarbonyl products from enol carbonates regioselectively with concomitant installation of a quaternary all-carbon center. The broad scope of the reaction has been demonstrated by successfully utilizing a range of enolates and external phenol nucleophiles.本研究开发了一种钯催化的稳定化烯醇负离子脱羧烯基化反应，该反应可从烯醇碳酸酯区域选择性地得到烯基化二羰基产物，同时构建全碳季碳中心。研究通过采用多种烯醇负离子与外部酚类亲核试剂，证实了该反应具有广泛的底物适用范围。