Latent Membrane Protein 1 and macrophage-derived TNFα synergistically activate and mobilize invadopodia to drive invasion of nasopharyngeal carcinoma

To investigate the effect of TNFα and EBV on invadopodia formation, we treated the EBV-positive and -negative NPC43 cells seeded on gelatin with or without TNFα We then performed gene expression profiling analysis using data obtained from RNA-seq of 4 different groups Comparative gene expression profiling analysis of RNA-seq data for -positive and -negative NPC43 EBV and the TNFα-treated counterpart