A bibliometric analysis of primary ovarian insufficiency from 2010 to 2020

This study aimed to carry out a bibliometric analysis of primary ovarian insufficiency (POI) from 2010 to 2020 and to reveal the research status and hotspots in the future. A total of 3087 articles and reviews related to POI published from 2010 to 2020 retrieved from the Web of Science Core Collection were used for bibliometric analysis. CiteSpace and VOSviewer were adopted to analyze countries and regions, organizations, authors, journals, keywords and co-cited references. The number of publications about POI increased year by year. The USA produced the largest number of publications and the most influence in this field. The main research directions of POI can be roughly divided into four aspects according to the analysis of keywords and co-cited references: genetic research of POI; stem cell therapy for patients with POI; prediction of ovarian function; and fertility preservation of cancer patients. Genetic research and stem cell therapy may become research hotspots in the future. This study might be the first bibliometric study to analyze publications of POI from multiple indicators, in order to provide new opinions for the research trends and possible hotspots of POI.本研究旨在针对2010至2020年的原发性卵巢功能不全（primary ovarian insufficiency, POI）领域开展文献计量分析，以揭示当前研究现状并研判未来研究热点。研究共纳入从Web of Science核心合集（Web of Science Core Collection）中检索到的2010至2020年发表的3087篇POI相关研究论文及综述，用于文献计量分析。本研究采用CiteSpace与VOSviewer两款工具，对该领域的国家与地区分布、科研机构、作者群体、刊载期刊、关键词及共被引参考文献进行了系统分析。结果表明，POI领域的发文量呈逐年增长趋势。美国是该领域发文总量最多且学术影响力最高的国家。基于关键词与共被引参考文献的分析结果，POI领域的核心研究方向可大致划分为四大类：POI的遗传学研究、POI患者的干细胞治疗、卵巢功能预测，以及癌症患者的生育力保存。遗传学研究与干细胞治疗或有望成为该领域未来的研究热点。本研究或为首个从多维度指标出发分析POI领域发文情况的文献计量研究，旨在为POI领域的研究趋势与潜在研究热点提供全新的学术见解。