Emetic or taste aversive compounds assessed for effects on Dictyostelium behaviour during chemotaxis.

A range of emetic or taste aversive compounds within the categories of tastants, cytotoxic agents, generalised receptor agonists/antagonists, and other compounds were selected for acute exposure to chemotaxing Dictyostelium cells. These compounds have a range of target receptors and/or mechanisms of action, as indicated. Compound concentrations employed in these Dictyostelium experiments (shown here) were derived from the experimental dose range for each compound used in emetic-related experiments in other species: F = Ferret; D = Dog; R = Rat; S = Shrew; C = Cat; H = Human. For in vivo experiments in the rat, the table refers to the dose at which pica was observed, for all other species it refers to the emetic dose. An effect on chemotaxis (defined as a significant change in cell velocity following acute treatment (see Figure 3 and 4)) is represented by Y (Yes), with no effect denoted N (No). * Caused conditioned taste aversion responses in the rat or data derived from in vitro studies.