Emetic or taste aversive compounds assessed for effects on Dictyostelium behaviour during chemotaxis.

A range of emetic or taste aversive compounds within the categories of tastants, cytotoxic agents, generalised receptor agonists/antagonists, and other compounds were selected for acute exposure to chemotaxing Dictyostelium cells. These compounds have a range of target receptors and/or mechanisms of action, as indicated. Compound concentrations employed in these Dictyostelium experiments (shown here) were derived from the experimental dose range for each compound used in emetic-related experiments in other species: F = Ferret; D = Dog; R = Rat; S = Shrew; C = Cat; H = Human. For in vivo experiments in the rat, the table refers to the dose at which pica was observed, for all other species it refers to the emetic dose. An effect on chemotaxis (defined as a significant change in cell velocity following acute treatment (see Figure 3 and 4)) is represented by Y (Yes), with no effect denoted N (No). * Caused conditioned taste aversion responses in the rat or data derived from in vitro studies.本数据集选取了味觉物质（tastants）、细胞毒素剂、广义受体激动剂/拮抗剂及其他类别中的多种催吐或味觉厌恶类化合物，用于对趋化盘基网柄菌（Dictyostelium）细胞进行急性暴露处理。此类化合物具备多样的靶点受体和/或作用机制，如前文所述。本研究中盘基网柄菌实验所采用的化合物浓度（如本文所示），源自其他物种中催吐相关实验所用的对应化合物实验剂量范围：F代表雪貂（Ferret），D代表犬（Dog），R代表大鼠（Rat），S代表鼩鼱（Shrew），C代表猫（Cat），H代表人类（Human）。针对大鼠的体内（in vivo）实验，表格所指为观察到异食癖（pica）时的剂量；对于其余物种，表格所指为催吐剂量。对趋化运动的影响（定义为急性处理后细胞速度发生显著变化，详见图3与图4）以"Y（是）"表示，无影响则以"N（否）"标注。* 该化合物可在大鼠体内诱发条件性味觉厌恶（conditioned taste aversion）反应，或其数据源自体外（in vitro）研究。