Asymmetric α‑Sulfonyl- and α‑Phosphoryl-Oxylation of Ketones by a Chiral Hypervalent Iodine(III)

An enantioselective direct oxygenation of propiophenone derivatives mediated by a catalytic or stoichiometric amount of new chiral non-C2-symmetric iodoarenes­(III) is reported. The reaction gives an easy entry to optically active α-sulfonyl- and α-phosphoryl oxyketones in respectable yields and enantioselectivities.本研究报道了一类由催化量或化学计量量的新型手性非C₂对称三价碘芳烃介导的苯丙酮衍生物对映选择性直接氧合反应。该反应可便捷地获得光学活性的α-磺酰基与α-膦酰基氧基酮，且产物拥有可观的产率与对映选择性。