Liver iTRAQ set 2 - contrast

This dataset was generated in an in vivo OECD TG 413 90-days nose-only inhalation study where Sprague-Dawley rats were exposed to either 3R4F cigarette smoke or aerosols of the carbon heated tobacco product (CHTP) 1.2, a heat-not-burn platform. The study contains additional test groups that were examined following a systems toxicology approach (please refer to the study page for more detail on the study design).
The liver proteome was characterized using iTRAQ (untargeted analysis). iTRAQ set 2 contains only female rat samples monitoring the exposure and recovery effect: each 8-plex labeling replicate set includes one sample of each 90 + 42-day sample and the corresponding female sample from the 90-day time point. This dataset contains the statistics resulting from the comparison of treatment and control groups.

本数据集源于一项符合经合组织（Organization for Economic Co-operation and Development，OECD）试验指南413的体内（in vivo）90天鼻吸入暴露试验，试验中向斯普拉-道来大鼠（Sprague-Dawley rats）分别暴露于3R4F卷烟烟气，以及碳基加热烟草制品（Carbon Heated Tobacco Product, CHTP）1.2的气溶胶——该产品属于加热不燃烧（heat-not-burn）平台。本研究还设置了额外试验组，采用系统毒理学方法开展检测分析，如需了解试验设计的详细细节，请参阅研究页面。研究采用同位素标记相对和绝对定量（isobaric Tags for Relative and Absolute Quantitation, iTRAQ）技术（非靶向分析）对肝脏蛋白质组进行了表征。iTRAQ标记组2仅包含雌性大鼠样本，用于监测暴露与恢复效应：每一组8重标记重复样本均包含一份90天+42天样本，以及来自90天时间点的对应雌性大鼠样本。本数据集包含了处理组与对照组对比分析所得的统计结果。