Integrated multi-omics analysis and experimental verification reveal the involvement of the PI3K/Akt signaling pathway in myometrial fibrosis of adenomyosis.

This analysis established comprehensive metabolomic profiles of adenomyosis patients and revealed widespread alterations in the metabolome within normal and fibrotic myometrium. Integrated analysis shown significant associations between metabolomic data and fibrosis . This study is the first to demonstrate that myometrial fibrosis represents a critical pathological mechanism in adenomyosis. These findings provide valuable insights into the pathophysiology of zdenomyosis and suggest antifibrotic treatment as a promising therapeutic strategy.