Additional file 7: Table S6. of Computational master-regulator search reveals mTOR and PI3K pathways responsible for low sensitivity of NCI-H292 and A427 lung cancer cell lines to cytotoxic action of p53 activator Nutlin-3

Result of F-Match analysis of the promoters of 62 genes up-regulated in Nutlin-3 insensitive cell lines. We show the list of transcription factors whose sites were detected as overrepresented in the promoters. We also show the respective PWMs linked to these transcription factors, the Yes/No ration of the site frequency and the LogFC for the expression of the transcription factor gene. In Tab CMA we give results of CMA analysis. 22 TF were revealed. (XLSX 59Â kb)本数据集为针对Nutlin-3不敏感细胞系中上调表达的62个基因的启动子进行F-Match分析的结果。本研究列出了其结合位点在上述启动子中被检测为显著富集的转录因子（Transcription Factor, TF）；同时提供了与这些转录因子关联的位置权重矩阵（Position Weight Matrix, PWM）、转录因子结合位点频率的Yes/No比值，以及该转录因子自身基因表达的对数倍变化（Logarithmic Fold Change, LogFC）。在CMA表格中给出了CMA分析的结果，共鉴定得到22个转录因子。本数据集文件格式为XLSX，大小为59 KB。