Graft-versus-Host Disease: Review

Abstract Graft-versus-host Disease (GVHD) is a major complication with high morbidity and mortality rates on patients undergoing hematopoietic stem cell transplantation. The ocular involvement, named ocular GVHD, may affect all structures of the eyes, but the lacrimal unit (lacrimal glands and ocular surface) is the main target of the inflammatory response mediated by the donor T cells. The development of dry eye disease is the main clinical ocular manifestation, and the association of a variety of therapeutics options is necessary. The aim of the review is to describe the clinical manifestations, diagnostic criteria, impact in quality of life, the current treatment and future perspectives of this disease that demands a multidisciplinary follow-up.

摘要：移植物抗宿主病（Graft-versus-host Disease, GVHD）是造血干细胞移植患者中发病率与死亡率均居高的严重并发症。其眼部受累类型称为眼GVHD，可累及眼部所有组织结构，但泪器（lacrimal unit，即泪腺与眼表）是供体T细胞介导的炎症反应的主要靶器官。干眼症的发生是该病最主要的临床眼部表现，临床治疗往往需要联合多种方案。本综述旨在阐述这一需要多学科随访的疾病的临床表现、诊断标准、对患者生活质量的影响、当前治疗手段及未来研究展望。