Screen for Small-Molecule Modulators of Circadian Rhythms Reveals Phenazine as Redox-State Modifying Clockwork Tuner. Supplemental data.

<strong>Please use the following password to open the files in the PDF flies.rar folder: VanderbiltU8211</strong> -<strong>PDF file</strong> containing the Positive Hits identified as clock modulators in the high-throughput cell-based screen performed at Vanderbilt University. <br> Positive Hits were classified as: <br> a)<em>Long period</em>: compounds that lengthens the circadian period when compared to the DMSO control. b)<em>Short period</em>: compounds that shortens the circadian period when compared to the DMSO control. c)<em>Enhanced amplitude</em>: compounds that enhance the circadian amplitude when compared to the DMSO control. d)<em>Transient suppression</em>: compounds that suppress circadian cycles to later reach full recovery of the circadian oscillation when compared to the DMSO control. <br> In order to facilitate the result interpretation it is also included a “How to read instructions and examples” file.

请使用以下密码解压PDF flies.rar文件夹内的文件：VanderbiltU8211。该文件夹内的PDF文件收录了范德堡大学（Vanderbilt University）开展的高通量细胞筛选中鉴定出的阳性命中物（Positive Hits），此类命中物均为昼夜节律时钟调节因子。

上述阳性命中物可划分为以下四类：
a) 长周期（Long period）：相较于二甲基亚砜（DMSO）对照组，可延长昼夜节律周期的化合物；
b) 短周期（Short period）：相较于二甲基亚砜（DMSO）对照组，可缩短昼夜节律周期的化合物；
c) 振幅增强（Enhanced amplitude）：相较于二甲基亚砜（DMSO）对照组，可增强昼夜节律振幅的化合物；
d) 瞬时抑制（Transient suppression）：相较于二甲基亚砜（DMSO）对照组，可暂时抑制昼夜节律循环，后续可完全恢复昼夜节律振荡的化合物。

为便于结果解读，本数据集还附带一份名为"How to read instructions and examples"的文件。