Comparison of canine CNG channel properties to human CNG channels.

The K0.5 values, Hill coefficients (Nh), cAMP efficacy (IcAMP/IcGMP), and L-cis Diltiazem block (Idil/I) of homomeric and heteromeric channels were determined at −60 mV. Averaged calcium to sodium permeability rations were calculated to be 1.52±0.52 (n = 5) for cA3 and 17.7±6.4 for A3+ B3 (n = 4). Comparison permeability ratios for hA3 were not available. Statistical values were SEM except for the two reports indicated with an * which were SD values.本实验于-60 mV电位下测定了同源寡聚体与异源寡聚体离子通道的K0.5值、希尔系数（Hill coefficient，记为Nh）、环磷酸腺苷（cAMP）功效（对应比值为IcAMP/IcGMP）以及L-顺式地尔硫卓（L-cis Diltiazem）阻滞效应（对应比值为Idil/I）。经计算，cA3组的平均钙钠通透比为1.52±0.52（n=5），A3+B3组为17.7±6.4（n=4）；目前暂无hA3通道的通透比对照数据。除标注星号（*）的两项报告采用标准差（Standard Deviation，SD）外，其余统计值均为标准误（Standard Error of the Mean，SEM）。