Screening pertactin-specific antibodies and evaluating competitive epitope recognition by native mass spectrometry

This study employs high-resolution native mass spectrometry (nMS) to define, compare, and mechanistically dissect the binding behavior of four therapeutic monoclonal antibodies (1E7, 2B1, 1F2, and 2E9) targeting the Bordetella pertussis antigen pertactin (Prn).