Novel and Predominant Pathogen Responsible for the Enterovirus-Associated Encephalitis in Eastern China

Enteroviruses (EV) have been increasingly identified as the causative agent for unknown etiological encephalitis in many parts of the world, but the long period surveillance for enterovirus-associated encephalitis (EAE) was not reported in China. From 2002-2012 in Zhejiang, Coxsackieviruses A9, B1, B2, B3, B4, B5; and echoviruses 3, 4, 6, 9, 14, 25, 30 were detected from the unknown etiological encephalitis cases, with coxsackievirus B4 been identified here for the first time. From 2002-2004 and 2010-2012, echovirus 30 was found to be the periodically predominant serotype for in the EAE. The molecular typing results showed that all the EV isolates from this study belonged to the human EV B (HEV B) family and were distributed in three clusters.肠道病毒（Enteroviruses, EV）已在全球多地被陆续证实为不明病因脑炎的致病病原体，但目前国内尚未有针对肠道病毒相关性脑炎（Enterovirus-associated encephalitis, EAE）的长期监测研究报道。2002年至2012年期间，浙江省的不明病因脑炎病例中检出柯萨奇病毒A9、B1、B2、B3、B4、B5以及埃可病毒3、4、6、9、14、25、30型，其中柯萨奇病毒B4型为本研究首次检出。2002-2004年及2010-2012年，埃可病毒30型被确定为该研究中肠道病毒相关性脑炎的周期性优势血清型。分子分型结果显示，本研究分离的所有肠道病毒毒株均属于人肠道病毒B族（Human EV B, HEV B），且可划分为三个聚类簇。