Binding affinities for selected pharmacophore hit compounds at the α1-adrenoceptors (ARs).

n represents the number of experiments, each performed in triplicate.Ø represents no binding at concentrations up to 100 µM.apKi (−Log Ki).bKi (inhibition constants) are the antilog of mean pKi.Ki values were calculated according to the equation of Cheng and Prusoff . Ki = IC50/1 + ([L]/KD) when [L] is the radioligand concentration and KD its dissociation constant.Aindicates significant differences from the α1A –AR (pBindicates significant differences from the α1B –AR (pDindicates significant differences from the α1D –AR (p