Binding affinities for selected pharmacophore hit compounds at the α1-adrenoceptors (ARs).

n represents the number of experiments, each performed in triplicate.Ø represents no binding at concentrations up to 100 µM.apKi (−Log Ki).bKi (inhibition constants) are the antilog of mean pKi.Ki values were calculated according to the equation of Cheng and Prusoff . Ki = IC50/1 + ([L]/KD) when [L] is the radioligand concentration and KD its dissociation constant.Aindicates significant differences from the α1A –AR (pBindicates significant differences from the α1B –AR (pDindicates significant differences from the α1D –AR (pn代表实验总次数，每组实验均进行三次平行重复。符号Ø表示当浓度最高达100 μM时未发生结合。apKi即负对数Ki值（−Log Ki）。bKi（抑制常数，inhibition constants）为平均pKi的反对数。Ki值按照程-普雷索夫（Cheng-Prusoff）公式计算：当[L]为放射性配体（radioligand）浓度、KD为其解离常数（dissociation constant）时，Ki = IC₅₀ / (1 + [L]/K_D)。A表示与α₁A-肾上腺素能受体（α₁A–AR）存在显著性差异，B表示与α₁B-肾上腺素能受体（α₁B–AR）存在显著性差异，D表示与α₁D-肾上腺素能受体（α₁D–AR）存在显著性差异（原文此处p值未完整标注）。