Dataset from van Dam PM, Locati ET, Ciconte G, Borrelli V, Heilbron F, Santinelli V, Vicedomini G, Monasky MM, Micaglio E, Giannelli L, Mecarocci V, Ćalović Ž, Anastasia L, Pappone C. Novel CineECG Derived From Standard 12-Lead ECG Enables Right Ventricle Outflow Tract Localization of Electrical Substrate in Patients With Brugada Syndrome. Circ Arrhythm Electrophysiol. 2020 Sep;13(9):e008524. doi: 10.1161/CIRCEP.120.008524. Epub 2020 Jul 28. PMID: 32755392.

Dataset from the article van Dam PM, Locati ET, Ciconte G, Borrelli V, Heilbron F, Santinelli V, Vicedomini G, Monasky MM, Micaglio E, Giannelli L, Mecarocci V, Ćalović Ž, Anastasia L, Pappone C. Novel CineECG Derived From Standard 12-Lead ECG Enables Right Ventricle Outflow Tract Localization of Electrical Substrate in Patients With Brugada Syndrome. Circ Arrhythm Electrophysiol. 2020 Sep;13(9):e008524. doi: 10.1161/CIRCEP.120.008524. Epub 2020 Jul 28. PMID: 32755392. This is the abstract: <strong>Background: </strong>In Brugada syndrome (BrS), diagnosed in presence of a spontaneous or ajmaline-induced type-1 pattern, ventricular arrhythmias originate from the right ventricle outflow tract (RVOT). We developed a novel CineECG method, obtained by inverse electrocardiogram (ECG) from standard 12-lead ECG, to localize the electrical activity pathway in patients with BrS. <strong>Methods: </strong>The CineECG enabled the temporospatial localization of the ECG waveforms, deriving the mean temporospatial isochrone from standard 12-lead ECG. The study sample included (1) 15 patients with spontaneous type-1 Brugada pattern, and (2) 18 patients with ajmaline-induced BrS (at baseline and after ajmaline), in whom epicardial potential duration maps were available; (3) 17 type-3 BrS pattern patients not showing type-1 BrS pattern after ajmaline (ajmaline-negative); (4) 47 normal subjects; (5) 18 patients with right bundle branch block (RBBB). According to CineECG algorithm, each ECG was classified as Normal, Brugada, RBBB, or Undetermined. <strong>Results: </strong>In patients with spontaneous or ajmaline-induced BrS, CineECG localized the terminal mean temporospatial isochrone forces in the RVOT, congruent with the arrhythmogenic substrate location detected by epicardial potential duration maps. The RVOT location was never observed in normal, RBBB, or ajmaline-negative patients. In most patients with ajmaline-induced BrS (78%), the RVOT location was already evident at baseline. The CineECG classified all normal subjects and ajmaline-negative patients at baseline as Normal or Undetermined, all patients with RBBB as RBBB, whereas all patients with spontaneous and ajmaline-induced BrS as Brugada. Compared with standard 12-lead ECG, CineECG at baseline had a 100% positive predictive value and 81% negative predictive value in predicting ajmaline test results. <strong>Conclusions: </strong>In patients with spontaneous and ajmaline-induced BrS, the CineECG localized the late QRS activity in the RVOT, a phenomenon never observed in normal, RBBB, or ajmaline-negative patients. The possibility to identify the RVOT as the location of the arrhythmogenic substrate by the noninvasive CineECG, based on the standard 12-lead ECG, opens new prospective for diagnosing patients with BrS.本数据集来自论文：van Dam PM、Locati ET、Ciconte G、Borrelli V、Heilbron F、Santinelli V、Vicedomini G、Monasky MM、Micaglio E、Giannelli L、Mecarocci V、Ćalović Ž、Anastasia L、Pappone C，刊载于《Circ Arrhythm Electrophysiol》2020年9月，第13卷第9期：e008524，DOI: 10.1161/CIRCEP.120.008524，2020年7月28日在线发表，PMID: 32755392，论文标题为《Novel CineECG Derived From Standard 12-Lead ECG Enables Right Ventricle Outflow Tract Localization of Electrical Substrate in Patients With Brugada Syndrome》。 **背景**：布鲁加达综合征（Brugada Syndrome, BrS）的诊断依据为自发或阿义马林诱导的1型心电图（electrocardiogram, ECG）表现，其室性心律失常起源于右心室流出道（right ventricle outflow tract, RVOT）。本研究开发了一种新型动态心电图（CineECG）方法，该方法通过标准12导联心电图经逆向心电成像得到，旨在定位布鲁加达综合征患者的电活动通路。 **方法**：CineECG可实现心电图波形的时空定位，从标准12导联心电图中提取平均时空等时线。本研究的研究队列包括：(1)15例存在自发1型布鲁加达心电图表现的患者；(2)18例经阿义马林诱导出现布鲁加达综合征的患者（包括基线状态及阿义马林给药后），此类患者均具备心外膜电位时长标测图数据；(3)17例阿义马林给药后未出现1型布鲁加达心电图表现的3型布鲁加达综合征患者（阿义马林试验阴性）；(4)47名正常对照受试者；(5)18例右束支传导阻滞（right bundle branch block, RBBB）患者。根据CineECG算法，每份心电图可被分类为正常、布鲁加达型、右束支传导阻滞型或不确定型。 **结果**：在存在自发或阿义马林诱导型布鲁加达综合征的患者中，CineECG检测到的平均终末时空等时向量定位在右心室流出道，与心外膜电位时长标测图所发现的致心律失常底物位置一致。正常对照、右束支传导阻滞患者及阿义马林试验阴性患者均未观察到右心室流出道定位表现。在多数阿义马林诱导型布鲁加达综合征患者（78%）中，基线状态下即可观察到右心室流出道定位特征。CineECG将基线状态下的正常受试者及阿义马林试验阴性患者均分类为正常或不确定型，将所有右束支传导阻滞患者分类为右束支传导阻滞型，而将所有自发型及阿义马林诱导型布鲁加达综合征患者分类为布鲁加达型。与标准12导联心电图相比，基线状态下的CineECG在预测阿义马林试验结果时具有100%的阳性预测值及81%的阴性预测值。 **结论**：在自发型及阿义马林诱导型布鲁加达综合征患者中，CineECG可将QRS波晚期活动定位至右心室流出道，该现象在正常对照、右束支传导阻滞患者及阿义马林试验阴性患者中均未出现。基于标准12导联心电图的无创CineECG可识别致心律失常底物的右心室流出道定位，这为布鲁加达综合征患者的诊断提供了新的研究方向。