MR-Guided Transcranial Focused Ultrasound Safely Enhances Interstitial Disperson of Large Polymeric Nanoparticles in the Living Brain

This study tested the viability of using MRI-guided transcranial focused ultrasound (MRgFUS) to modify the interstitial space in the living brain. As a non-invasive technique, success in generating spatially controlled, non-destructive changes could lead to clinical applications such as enhancing delivery of therapeutics and altering fluid and pressure dynamics. The research involved the use of computer simulations for treatment planning and MRI acoustic radiation force impulse imaging for target validation. Additionally, Evans blue dye or nanoparticle probes were utilized to assess changes in the interstitium.This dataset includes a variety of histological, acoustic simulation, and electrophysiological images and tabular data of compressional acoustic properties of skull and brain tissue and physiochemical properties of nanoparticles.

本研究旨在探讨利用磁共振引导的经颅聚焦超声（MRgFUS）技术在活体大脑中调节间质空间的可能性。作为一种非侵入性技术，若能在空间上精确控制并实现非破坏性变化，则有望在临床应用中提升药物输送效果，并调节液体和压力动力学。研究过程中，采用了计算机模拟进行治疗方案设计，以及利用磁共振声辐射力脉冲成像进行目标验证。此外，本研究还使用了伊文思蓝染料或纳米颗粒探针来评估间质的变化。该数据集包含了多种组织学、声学模拟和电生理图像，以及颅骨和脑组织压缩声学特性以及纳米颗粒的物化性质的相关表格数据。