Additional file 1 of The impact of cesarean delivery on infant DNA methylation

Additional file 1 Table S1. Information of primers used in targeted bisulfite sequencing assay. Table S2. Differentially methylated loci between vaginal delivery and CDMR group from the Methylation Chip. Table S3. Differentially methylated loci between vaginal delivery and CDMR group from targeted bisulfite sequencing assay. Table S4. The comparison of M-values between VD and CDMR group using multiple linear regression. Table S5. The estimate proportions of cell type in cord blood. Table S6. Differentially methylated CpG sites between VD and CDMR group from the Methylation Chip analyzed by M values, under the threshold difference in the mean β value |Δβ| ≥ 10%. Fig. S1. A volcano plot of lg-transformed P values vs differences in DNA methylation (b-value) between VD and CDMR group.

附加文件1 表S1：靶向亚硫酸氢盐测序（targeted bisulfite sequencing）实验所用引物的详细信息；表S2：基于甲基化芯片（Methylation Chip）分析得到的阴道分娩组与CDMR组间的差异甲基化位点；表S3：基于靶向亚硫酸氢盐测序实验得到的阴道分娩组与CDMR组间的差异甲基化位点；表S4：采用多元线性回归分析比较阴道分娩（vaginal delivery，VD）组与CDMR组的M值差异；表S5：脐带血样本的细胞类型估算比例；表S6：以平均β值差值|Δβ|≥10%为筛选阈值，基于M值分析甲基化芯片得到的阴道分娩组与CDMR组间的差异甲基化CpG位点；图S1：阴道分娩组与CDMR组间DNA甲基化b值差值与对数转换后P值的火山图。