Parameter estimates of the final population model.

Definition of abbreviations: Emax = maximal effect of the drug; A50 = amount of acetazolamide that instantaneously induces 50% of putative maximal effect on serum bicarbonate; Bicar0 = bicarbonate baseline level; MV0 = minute ventilation at baseline level; PaCO20 = PaCO2 at baseline level; BSV = between-subject variability; kout = first-order constant rate for acetazolamide effect kinetics; %rse = percent relative standard error; SAPS II = simplified acute physiology score II at intensive care unit admission; NA = not applicable; Furosemide50 = amount of furosemide that instantaneously induces 50% of putative maximal effect on serum bicarbonate.缩写定义如下：Emax = 药物最大效应；A50 = 可瞬时诱导血清碳酸氢盐产生推定最大效应50%的乙酰唑胺（acetazolamide）剂量；Bicar0 = 碳酸氢盐基线水平；MV0 = 基线分钟通气量；PaCO20 = 基线动脉血二氧化碳分压（PaCO2）；BSV = 受试者间变异性（between-subject variability）；kout = 乙酰唑胺效应动力学的一级速率常数；%rse = 相对标准误差百分比（percent relative standard error）；SAPS II = 重症监护病房入院时的简化急性生理学评分II（simplified acute physiology score II）；NA = 不适用；Furosemide50 = 可瞬时诱导血清碳酸氢盐产生推定最大效应50%的呋塞米（furosemide）剂量。