The PR8 and PR8mut viruses were produced by reverse genetics using the pHW191-PB2, pHW192-PB1, pHW193-PA, pHW194-HA, pHW195-NP, pHW196-NA, pHW197-M (wild type PR8) or pHW197-Mmut (PR8mut), and pHW198-
Isolate and sequence human viruses from Michigan, Philadelphia, and Hong Kong and generate viruses via reverse-genetics with representative HA and NA genes from circulating strains to support serologi
Crimean Congo hemorrhagic fever virus (CCHFV) is a negative-strand RNA virus of the family Bunyaviridae (genus: Nairovirus). In humans, CCHFV causes fever, hemorrhage, severe thrombocytopenia, and hig
*Rescue efficiency defined in Table 1.For each combination, the rescue was repeated at least 3 times.Rescue efficiency of reassortants with NP and NS containing modified packaging signals.
