Supplementary Material for: A Case Report of Mixed Acinar-Neuroendocrine Pancreatic Carcinoma (MANEC): A Rare Subtype of Pancreatic Cancer

Introduction: Mixed acinar-neuroendocrine carcinoma (MANEC) is a rare variant of pancreatic carcinoma, the morphology of which shows features of both acinar cell carcinoma and neuroendocrine carcinomas. To date, only approximately 70 cases of MANEC have been reported.
Case Presentation: We report a rare case of a 63-year-old male cirrhotic patient who presented with a pancreatic body/tail mass, which was later confirmed to be a mixed acinar and neuroendocrine carcinoma. He was initiated on neoadjuvant chemotherapy with Folfirinox, but unfortunately died before surgery.
Conclusion: MANEC is a rare sporadic tumor of the pancreas. Further studies on the clinicopathological behavior of MANEC are needed to help better understand the disease and establish standardized management.

引言：混合腺泡-神经内分泌癌（Mixed acinar-neuroendocrine carcinoma, MANEC）是胰腺癌的一种罕见亚型，其组织形态同时兼具腺泡细胞癌与神经内分泌癌的特征。截至目前，全球仅报道约70例MANEC病例。
病例报告：本文报道1例罕见病例：患者为63岁男性肝硬化患者，因胰体尾肿物就诊，后经病理证实为混合腺泡神经内分泌癌。患者接受了Folfirinox方案新辅助化疗，但不幸在手术前离世。
结论：MANEC是一种罕见的胰腺散发性肿瘤。目前仍需开展更多针对MANEC临床病理行为的研究，以助力更深入地认识该疾病并建立标准化诊疗规范。