Benchmark WGBS data (sample 4 in 3 versus 3 sample comparison)

Benchmark WGBS data (sample 4 in 3 versus 3 sample comparison)<br><br>This file contains simulated benchmark WGBS data for 1 sample from a 3 vs 3 comparison saved as a `.txt.gz` (compressed text file). The tab-delimited text file contains four columns: chromosome, position, number of methylated reads, and total number of reads coverage.<br><br>This benchmark data was created to mimic the properties of real WGBS data in order to evaluate the method dmrseq (described in the preprint at https://doi.org/10.1101/183210). This was done by splitting a set of biological replicates (controls) into two artificial groups and adding methylation differences to randomly selected regions. Differences are added between the first half of samples and the second half of samples. More methodological details and a script to reproduce the generation of this data file is available at the companion repository: https://github.com/kdkorthauer/dmrseqPaper.

基准全基因组亚硫酸氢盐测序（Whole Genome Bisulfite Sequencing, WGBS）数据集（3对3样本比较中的第4号样本）

本文件包含来自3对3样本比较的1个样本的模拟基准WGBS数据集，保存为`.txt.gz`格式（压缩文本文件）。该制表符分隔的文本文件包含四列：染色体、基因组位置、甲基化读段数、总覆盖读段数。

本基准数据集旨在模拟真实WGBS数据的特征，以用于评估dmrseq方法（相关预印本详见https://doi.org/10.1101/183210）。其构建方式为：将一组生物学重复样本（对照组）划分为两个人工分组，并在随机选取的基因组区域中引入甲基化差异，差异设置于样本前半部分与后半部分之间。

更多方法学细节与复现本数据集生成过程的脚本，可参见配套仓库：https://github.com/kdkorthauer/dmrseqPaper。