Additional file 1 of Investigating causal relationships between exposome and human longevity: a Mendelian randomization analysis

Additional file 1: Table S1. Details of the instruments used as proxy risk factors for longevity. Table S2. Description of independent exposure GWAS used in validation. Table S3. Estimates of inverse variance weighted method for significant associations between genetically predicted exposures and longevity. Table S4. Sensitivity analysis results for the metabolites identified in secondary analysis. Table S5. Pleiotropy and heterogeneity analyses for the association between exposures and Alzheimer's disease in secondary analysis. Table S6. The Mendelian randomization association of individual SNPs of screening traits in primary analysis. Table S7. Mendelian randomization results of validation using independent exposure GWAS. Table S8. Mendelian randomization results of validation using dataset of 90th percentile longevity. Table S9. Mendelian randomization results of validation using dataset of 99th percentile longevity. Table S10. List of exposures in the present study. Table S11. Exposures identified significantly and suggestively associated with 90th percentile longevity in primary analyses. Table S12. Exposures identified significantly and suggestively associated with 99th percentile longevity in secondary analyses.

补充材料1：表S1。作为长寿代理风险因素的工具变量（instrumental variable）详情。
表S2。验证研究中所用的独立暴露全基因组关联研究（Genome-Wide Association Study，GWAS）概况。
表S3。遗传预测暴露与长寿间显著关联的逆方差加权法估计结果。
表S4。次要分析中鉴定出的代谢物的敏感性分析结果。
表S5。次要分析中暴露与阿尔茨海默病间关联的多效性与异质性分析结果。
表S6。主要分析中筛选性状的单个单核苷酸多态性（Single Nucleotide Polymorphism，SNP）的孟德尔随机化关联结果。
表S7。使用独立暴露全基因组关联研究（GWAS）进行验证的孟德尔随机化结果。
表S8。使用90百分位长寿数据集进行验证的孟德尔随机化结果。
表S9。使用99百分位长寿数据集进行验证的孟德尔随机化结果。
表S10。本研究中的暴露因素列表。
表S11。主要分析中与90百分位长寿存在显著及提示性关联的暴露因素。
表S12。次要分析中与99百分位长寿存在显著及提示性关联的暴露因素。