Crystal structure of Pim1 kinase in complex with inhibitor 2-[(trans-4-aminocyclohexyl)amino]-4-{[3-(trifluoromethyl)phenyl]amino}pyrido[4,3-d]pyrimidin-5(6H)-one

Protein Data Bank Japan2023-09-20 更新2026-03-21 收录

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Crystal structure of Pim1 kinase in complex with inhibitor 2-[(trans-4-aminocyclohexyl)amino]-4-{[3-(trifluoromethyl)phenyl]amino}pyrido[4,3-d]pyrimidin-5(6H)-one Descriptor: 2-[(trans-4-aminocyclohexyl)amino]-4-{[3-(trifluoromethyl)phenyl]amino}pyrido[4,3-d]pyrimidin-5(6H)-one, PIM1 consensus peptide, Serine/threonine-protein kinase pim-1 Authors: Lee, S.J, Han, B.G, Cho, J.W, Choi, J.S, Lee, J.K, Song, H.J, Koh, J.S, Lee, B.I. Deposit date: 2013-03-27 Release date: 2013-08-28 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Crystal structure of pim1 kinase in complex with a pyrido[4,3-d]pyrimidine derivative suggests a unique binding mode. Plos One, 8, 2013

与抑制剂2-[(反式-4-氨基环己基)氨基]-4-{[3-(三氟甲基)苯基]氨基}吡啶并[4,3-d]嘧啶-5(6H)-酮结合的Pim1激酶晶体结构描述项：2-[(反式-4-氨基环己基)氨基]-4-{[3-(三氟甲基)苯基]氨基}吡啶并[4,3-d]嘧啶-5(6H)-酮、PIM1共有肽、丝氨酸/苏氨酸蛋白激酶pim-1 作者：Lee S.J、Han B.G、Cho J.W、Choi J.S、Lee J.K、Song H.J、Koh J.S、Lee B.I. 提交日期：2013-03-27 发布日期：2013-08-28 最后修改时间：2023-09-20 实验方法：X射线衍射（分辨率2.4埃）引用文献：结合吡啶并[4,3-d]嘧啶衍生物的Pim1激酶晶体结构揭示独特结合模式，《PLOS ONE》，第8卷，2013年

创建时间：

2013-03-27