<i>In vitro</i> ligand displacement by thymoquinone.

NIAID Data Ecosystem2026-03-07 收录

阿片受体配体

药物-受体结合研究

数据链接：

https://figshare.com/articles/dataset/_In_vitro_ligand_displacement_by_thymoquinone_/287085 数据链接链接失效反馈

官方服务：

资源简介：

a)20–50% = moderate displacement (Abbr.: MOR = μ-opioid receptor, KOR = ê-opioid receptor, DOR = δ-opioid receptor).

创建时间：

2012-06-29

Conformational Determinants of Agonist versus Antagonist Properties of [d-Pen 2 ,d-Pen 5 ]Enkephalin (DPDPE) Analogs at Opioid Receptors. Comparison of X-ray Crystallographic Structure, Solution 1 H NMR Data, and Molecular Dynamic Simulations of [l-Ala 3 ]DPDPE and [d-Ala 3 ]DPDPE

阿片受体配体

肽类构效关系

c-[d-Pen2,d-Pen5]enkephalin (DPDPE, 1) is a cyclic, constrained, highly potent, δ opioid receptor selective peptide agonist. Substitution of Gly3 with l-Ala in DPDPE to give [l-Ala3]DPDPE (2) has been

NIAID Data Ecosystem80

Structure-Based Discovery of New Antagonist and Biased Agonist Chemotypes for the Kappa Opioid Receptor

药物虚拟筛选

阿片受体配体

The ongoing epidemics of opioid overdose raises an urgent need for effective antiaddiction therapies and addiction-free painkillers. The κ-opioid receptor (KOR) has emerged as a promising target for b

NIAID Data Ecosystem40

Opioid Receptor Modulators with a Cinnamyl Group

阿片受体配体

镇痛药物开发

To obtain selective and potent opioid receptor ligands, we synthesized dehydro derivatives of alvimopan and found compound (28f), a selective but modest affinity MOR antagonist weaker than alvimopan (

NIAID Data Ecosystem30

Versatile Picklocks To Access All Opioid Receptors: Tuning the Selectivity and Functional Profile of the Cyclotetrapeptide c[Phe‑d‑Pro-Phe-Trp] (CJ-15,208)

阿片受体配体

镇痛药物开发

Recently, the tryptophan-containing noncationizable opioid peptides emerged with atypical structure and unexpected in vivo activity. Herein, we describe analogs of the naturally occurring mixed κ/μ-li

NIAID Data Ecosystem40

Versatile Picklocks To Access All Opioid Receptors: Tuning the Selectivity and Functional Profile of the Cyclotetrapeptide c[Phe‑d‑Pro-Phe-Trp] (CJ-15,208)

阿片受体配体

疼痛管理药物开发

NIAID Data Ecosystem30