Mycosis fungoides

Mycosis fungoides (MF) is the most common and best studied of cutaneous T-cell lymphoma (CTCL). Three clinical cutaneous stages have been described (patch, plaque and tumor) as the disease progress developing also the disease lymph node, peripheral blood or systemic involvement in late stages. Clinical and pathologic diagnosis of early MF stages (patch and plaque) is difficult as its morphologic similarity to inflammatory dermatoses and low proportion of tumoral cells. 14 MF and 15 reactive skin lesions were hybridized on a 8 x 15K human miRNA one-color platform (Agilent) containing probes for 723 human miRNAs.